NRG Stadium, Houston — The San Francisco 49ers (5–2) will face off against the Houston Texans (2–4) on Sunday, October 26, 2025, in what promises to be a hard-fought interconference battle.

Betting Odds (via BetMGM):

• Spread: Houston -1.5 (-110), San Francisco +1.5 (-110)

• Moneyline: Houston -125, San Francisco +105

• Total (O/U): 41.5 points

Injury Report:
Both teams enter Week 8 with no major injuries listed

, giving fans a chance to see two healthy rosters square off.

Game Details:

• Venue: NRG Stadium

• Time: 1:00 p.m. ET

• TV: FOX

• Streaming (local viewers): Fubo (Stream now)

• Tickets:

  Available on StubHub 

Stats to Know:

• The 49ers have allowed 19.7 points per game, nearly identical to the 21.2 points the Texans have averaged this season.

• San Francisco’s defense is giving up

  317.4 yards per game, slightly more than Houston’s 304.3 yards of total offense.

• The 49ers average 20.7 points per game, six points higher than the Texans’ defensive average of

  14.7 points allowed.

• Houston’s defense has surrendered 274.2 yards per game, while San Francisco’s offense generates 366.6 yards per game on average.

Both teams will be looking to gain momentum heading into midseason — with San Francisco aiming to solidify its playoff standing and Houston eager to pull off an upset at home.