NRG Stadium, Houston — The San Francisco 49ers (5–2) will face off against the Houston Texans (2–4) on Sunday, October 26, 2025, in what promises to be a hard-fought interconference battle.
Betting Odds (via BetMGM):
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Spread:Â Houston -1.5 (-110), San Francisco +1.5 (-110)
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Moneyline:Â Houston -125, San Francisco +105
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Total (O/U):Â 41.5 points
Injury Report:
Both teams enter Week 8Â with no major injuries listed
, giving fans a chance to see two healthy rosters square off.
Game Details:
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Venue:Â NRG Stadium
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Time:Â 1:00 pm ET
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TV:Â FOX
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Streaming (local viewers): Fubo (Stream now)
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Tickets:
Available on StubHub
Stats to Know:
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The 49ers have allowed 19.7 points per game, nearly identical to the 21.2 points the Texans have averaged this season.
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San Francisco’s defense is giving up
317.4 yards per game, slightly more than Houston’s 304.3 yards of total offense.
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The 49ers average 20.7 points per game, six points higher than the Texans’ defensive average of
14.7 points allowed.
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Houston’s defense has surrendered 274.2 yards per game, while San Francisco’s offense generates 366.6 yards per game on average.
Both teams will be looking to gain momentum heading into midseason — with San Francisco aiming to solidify its playoff standing and Houston eager to pull off an upset at home.
Both teams will be looking to gain momentum heading into mid-season – with San Francisco aiming to solidify its playoff status and Houston eager to pull off the upset at home.
