An AFC East–NFC South clash with major implications awaits as the Buffalo Bills (6–3) host the Tampa Bay Buccaneers (4–5) this Sunday, November 16, 2025, at Highmark Stadium.

With both teams fighting to stay alive in the playoff race, this matchup promises intensity, urgency, and high-stakes football on every snap.

How to Watch Tampa Bay Buccaneers vs. Buffalo Bills

Venue: Highmark Stadium
Kickoff Time: 1:00 p.m. ET
Streaming (local): Fubo (Stream now)
TV Broadcast: CBS
Attending the game? Tickets available on StubHub

Buccaneers vs. Bills — Betting Odds

Spread: Bills -6.5 (-110), Buccaneers +6.5 (-110)
Moneyline: Bills -260, Buccaneers +210
Total: 47.5
Over/Under: Over -110, Under -110
Odds formatted based on structure via BetMGM.

Bills vs. Buccaneers — Recent Head-to-Head Results

Bills lead the all-time series 9–4–0, maintaining a strong advantage over Tampa Bay in recent matchups.

Week 11 Injury Reports

Buffalo Bills

• WR Stefon Diggs — DNP (Rest)

• RB James Cook — DNP (Ankle)

• LT Dion Dawkins — DNP (Knee)

• LB Matt Milano — Limited (Groin)

• DT Ed Oliver — DNP (Shoulder)

• S Jordan Poyer — Full (Neck)

• CB Kaiir Elam — DNP (Hamstring)

• DE Greg Rousseau — Limited (Back)

Tampa Bay Buccaneers

• QB Baker Mayfield — Limited (Elbow)

• WR Mike Evans — DNP (Hamstring)

• DE Joe Tryon-Shoyinka — DNP (Hip)

• CB Carlton Davis — Full (Ankle)

• RB Rachaad White — DNP (Toe)

• DT Calijah Kancey — DNP (Knee)

Stats to Know

• Buffalo averages 27.5 points per game, outpacing Tampa Bay’s defensive average of 29.1 points allowed.

• The Buccaneers defense gives up 404.2 yards per game, compared to the Bills’ 371.5 yards of offense.

• The Bills allow 20.8 points per game, nearly matching Tampa Bay’s scoring average of 21.3.

• Tampa Bay generates 315.4 yards of offense, while Buffalo’s defense allows 344.9 yards, suggesting the Bucs may need explosive plays to stay competitive.